We have our first trailer for Martin Scorsese’s long-awaited “Killers of the Flower Moon” starring Leonardo DiCaprio and Robert De Niro.

The film, which will premiere at the Cannes Film Festival on May 20, also stars Alabama native and Grammy-winning musician Jason Isbell.

The premise, according to Apple’s official website: “At the turn of the 20th century, oil brought a fortune to the Osage Nation, who became some of the richest people in the world overnight. The wealth of these Native Americans immediately attracted white interlopers, who manipulated, extorted and stole as much Osage money as they could before resorting to murder.”

Based on David Grann’s 2017 book of the same name, the film explores the “improbable romance” Ernest Burkhart (DiCaprio) and Mollie Kyle (Lily Gladstone) in what Apple calls “an epic western crime saga, where real love crosses paths with unspeakable betrayal.” The film also stars De Niro, Jesse Plemons, Brendan Fraser, John Lithgow, Isbell, Sturgill Simpson and others.

It marks the sixth collaboration between Scorsese and DiCaprio after “Gangs of New York,” “The Aviator,” “The Departed,” “Shutter Island” and “The Wolf of Wall Street.” It marks the 10th between the director and De Niro after classics like “Mean Streets,” “Taxi Driver,” “Raging Bull” and “Goodfellas.”

Isbell plays a character named Bill Smith. We did not spot him in this teaser trailer, but he remains listed in the film’s cast. It marks his second on-screen credit in a fictional role following an appearance as a wedding guest in “Deadwood: The Movie” back in 2019. Isbell has also appeared as himself on the Showtime series “Billions.”

DiCaprio tweeted the trailer Thursday morning, noting this is one he’s excited to share with fans.

“#KillersOfTheFlowerMoon will exclusively be in theatres from @ParamountMovies & @AppleFilms this October,” he wrote. “It’s a project I am proud of & I cannot wait to share it with you all.”

The film’s runtime is reported to be 206 minutes. In a recent interview with Deadline, Scorsese was asked about the near 3.5-hour length. He said, “I say to the audience out there, if there is an audience for this kind of thing, ‘Make a commitment. Your life might be enriched. This is a different kind of picture; I really think it is. Well, I’ve given it to you, so hey, commit to going to a theater to see this.’”

“Killers of the Flower Moon” will release in theaters everywhere Oct. 20, 2023. It will later stream on Apple TV+. Watch the trailer above.